{"id":9468,"date":"2025-11-24T11:07:01","date_gmt":"2025-11-24T09:07:01","guid":{"rendered":"https:\/\/verite.gr\/?p=9468"},"modified":"2025-11-24T11:07:01","modified_gmt":"2025-11-24T09:07:01","slug":"epanastasi-stin-antigiransi-yamanaka-factors-i-ereyna-toy-cambridge-kai-pos-epistimones-nikisan-ton-chrono","status":"publish","type":"post","link":"https:\/\/staging.upflow.gr\/?p=9468","title":{"rendered":"\u0395\u03c0\u03b1\u03bd\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u0391\u03bd\u03c4\u03b9\u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7: Yamanaka Factors \u03ba\u03b1\u03b9 \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c4\u03bf\u03c5 Cambridge"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">\u03a0\u03ce\u03c2 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03bf\u03bd\u03b5\u03c2 \u03bd\u03af\u03ba\u03b7\u03c3\u03b1\u03bd \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf;<\/h3>\n\n\n\n<p>\u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03c9\u03bd&nbsp;<strong>Yamanaka factors<\/strong>&nbsp;&#8211; \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd Oct4, Sox2, Klf4 \u03ba\u03b1\u03b9 c-Myc &#8211; \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03be\u03b5\u03c0\u03b5\u03c1\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd iPSC \u03ba\u03b1\u03b9 \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2. \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c3\u03c4\u03bf&nbsp;<strong>Babraham Institute<\/strong>&nbsp;\u03c4\u03bf\u03c5 Cambridge \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03bf \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae, \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c9\u03c2&nbsp;<strong>maturation-phase transient reprogramming (MPTR)<\/strong>, \u03c0\u03bf\u03c5 \u00ab\u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9\u00bb \u03c4\u03bf\u03bd \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c7\u03c1\u03cc\u03bd\u03bf \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n\n\n\n<p><strong>\u03a4\u03b9 \u03ad\u03ba\u03b1\u03bd\u03b1\u03bd \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2:<\/strong><\/p>\n\n\n\n<p>\u0391\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ae, \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5&nbsp;<strong>50 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2<\/strong>, \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b1\u03c0\u03bf\u03bc\u03cc\u03bd\u03c9\u03c3\u03b1\u03bd \u03ad\u03bd\u03b1 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03c0\u03b1\u03c1\u03ac\u03b8\u03c5\u03c1\u03bf: \u03b5\u03be\u03ad\u03b8\u03b5\u03c3\u03b1\u03bd \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 (fibroblasts) \u03c3\u03b5 Yamanaka factors \u03b3\u03b9\u03b1 \u03bc\u03cc\u03bb\u03b9\u03c2&nbsp;<strong>13 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2<\/strong><\/p>\n\n\n\n<p>\u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1, \u03c3\u03c4\u03b1\u03bc\u03ac\u03c4\u03b7\u03c3\u03b1\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ac\u03c6\u03b7\u03c3\u03b1\u03bd \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03bf\u03cd\u03bd \u03c5\u03c0\u03cc \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2.&nbsp;<\/p>\n\n\n\n<p>\u039c\u03b5 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5&nbsp;<strong>\u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03bf\u03cd<\/strong>&nbsp;(epigenetic clock) \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5&nbsp;<strong>\u03c4\u03c1\u03b1\u03bd\u03c3\u03ba\u03c1\u03b9\u03c0\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong>, \u03b4\u03b9\u03b1\u03c0\u03af\u03c3\u03c4\u03c9\u03c3\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u201c\u03b3\u03cd\u03c1\u03b9\u03c3\u03b1\u03bd\u201d \u03c3\u03b5 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c3\u03b5 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5&nbsp;<strong>30 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b1<\/strong>.&nbsp; \u03a0\u03b1\u03c1\u03ac \u03c4\u03b7\u03bd \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2, \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b1\u03bd \u03c4\u03b7\u03bd \u03c4\u03b1\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03c9\u03c2 \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 &#8211; \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae&nbsp;<strong>\u03b4\u03b5\u03bd \u201c\u03be\u03b5\u03c7\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5\u201d \u03b7 \u03b5\u03be\u03b5\u03b9\u03b4\u03af\u03ba\u03b5\u03c5\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2<\/strong>.&nbsp;<\/p>\n\n\n\n<p>\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03bf\u03b9 \u201c\u03b1\u03bd\u03b1\u03b3\u03b5\u03bd\u03bd\u03b7\u03bc\u03ad\u03bd\u03b1\u201d \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03b1\u03c1\u03ae\u03b3\u03b1\u03b3\u03b1\u03bd&nbsp;<strong>\u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf<\/strong>&nbsp;\u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03b3\u03ae\u03c1\u03b1 \u03bc\u03b5 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1, \u03ba\u03b1\u03b9 \u03c3\u03b5 in vitro \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b5\u03c0\u03bf\u03cd\u03bb\u03c9\u03c3\u03b7\u03c2 (scratch assay) \u03bc\u03b5\u03c4\u03b1\u03ba\u03b9\u03bd\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03b9\u03bf \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u00ab\u03ba\u03bb\u03b5\u03af\u03c3\u03bf\u03c5\u03bd\u00bb \u03ad\u03bd\u03b1 \u03c4\u03b5\u03c7\u03bd\u03b7\u03c4\u03cc \u03c4\u03c1\u03b1\u03cd\u03bc\u03b1.&nbsp;<\/p>\n\n\n\n<p><strong>\u0393\u03b9\u03b1\u03c4\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0397 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae&nbsp;<strong>MPTR<\/strong>&nbsp;\u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af&nbsp;<strong>\u03b1\u03bd\u03b1\u03b6\u03c9\u03bf\u03b3\u03cc\u03bd\u03b7\u03c3\u03b7<\/strong>&nbsp;(rejuvenation) \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03c3\u03b5 \u03c0\u03bb\u03ae\u03c1\u03b7 \u03c0\u03bf\u03bb\u03c5\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1, \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03cc\u03b3\u03ba\u03c9\u03bd.&nbsp;<\/li>\n\n\n\n<li>\u0397&nbsp;<strong>\u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2<\/strong>&nbsp;\u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bd\u03b1\u03ba\u03c4\u03ae\u03c3\u03bf\u03c5\u03bd \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.&nbsp;<\/li>\n\n\n\n<li>\u0397 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u201c\u03bc\u03b5\u03c4\u03b1\u03bd\u03ac\u03c4\u03b5\u03c5\u03c3\u03b7\u201d \u03c4\u03c9\u03bd \u03b9\u03bd\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03bf\u03cd\u03bb\u03c9\u03c3\u03b7\u03c2 \u03b1\u03bd\u03bf\u03af\u03b3\u03b5\u03b9 \u03c4\u03bf \u03b4\u03c1\u03cc\u03bc\u03bf \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd&nbsp;<strong>\u03b1\u03bd\u03b1\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae<\/strong>&nbsp;(\u03c0.\u03c7. \u03b3\u03b9\u03b1 \u03c4\u03c1\u03b1\u03cd\u03bc\u03b1\u03c4\u03b1, \u03b7\u03bb\u03b9\u03ba\u03b9\u03b1\u03ba\u03ac \u03ad\u03bb\u03ba\u03b7).<\/li>\n<\/ul>\n\n\n\n<p><strong>\u03a0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03bb\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong><\/p>\n\n\n\n<p>\u039f \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 MPTR \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b1\u03c0\u03bf\u03c3\u03b1\u03c6\u03b7\u03bd\u03b9\u03c3\u03c4\u03b5\u03af: \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03c0\u03bf\u03b9\u03bf\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03c4\u03bf\u03bc\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u201c\u03b4\u03b9\u03b1\u03c6\u03b5\u03cd\u03b3\u03bf\u03c5\u03bd\u201d \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd &#8211; \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae, \u03c0\u03bf\u03b9\u03bf\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03c4\u03cc\u03c0\u03bf\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03af \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c4\u03b1\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1.&nbsp; \u0397 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1: \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b5\u03af \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b8\u03b1 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b7\u03b8\u03bf\u03cd\u03bd \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03ae \u03c0\u03c1\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2. \u0397 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03ad\u03c7\u03b5\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af&nbsp;<strong>\u03c3\u03b5 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong>, \u03cc\u03c7\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c3\u03b5 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03ae \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2, \u03ba\u03b9 \u03ad\u03c4\u03c3\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1.<\/p>\n\n\n\n<p>\u0395\u03af\u03bd\u03b1\u03b9 \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd \u03b1\u03c5\u03c4\u03ae \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03bc\u03b9\u03b1 \u03b5\u03c0\u03b1\u03bd\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u0391\u03bd\u03c4\u03b9\u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7;<\/p>\n\n\n\n<p>\u0397 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c4\u03bf\u03c5&nbsp;<strong>Cambridge \/ Babraham Institute<\/strong>&nbsp;\u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd Yamanaka factors \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c3\u03c4\u03b5\u03c1\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03b3\u03b9\u03b1&nbsp;<strong>\u03bc\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b6\u03c9\u03bf\u03b3\u03cc\u03bd\u03b7\u03c3\u03b7<\/strong>&nbsp;\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u201c\u03b3\u03cd\u03c1\u03b9\u03c3\u03bc\u03b1\u201d \u03c4\u03bf\u03c5 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5&nbsp;<strong>30 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1<\/strong>, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b1\u03bd\u03bf\u03af\u03b3\u03b5\u03b9 \u03ad\u03bd\u03b1\u03bd \u03c0\u03bf\u03bb\u03bb\u03ac \u03c5\u03c0\u03bf\u03c3\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03b4\u03c1\u03cc\u03bc\u03bf \u03b3\u03b9\u03b1 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"573\" src=\"https:\/\/staging.upflow.gr\/wp-content\/uploads\/2025\/11\/MOUSSAS-1024x573.jpg\" alt=\"\" class=\"wp-image-9469\" style=\"width:536px;height:auto\" srcset=\"https:\/\/staging.upflow.gr\/wp-content\/uploads\/2025\/11\/MOUSSAS-1024x573.jpg 1024w, https:\/\/staging.upflow.gr\/wp-content\/uploads\/2025\/11\/MOUSSAS-300x168.jpg 300w, https:\/\/staging.upflow.gr\/wp-content\/uploads\/2025\/11\/MOUSSAS-768x430.jpg 768w, https:\/\/staging.upflow.gr\/wp-content\/uploads\/2025\/11\/MOUSSAS.jpg 1170w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u03a0\u03ce\u03c2 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03bf\u03bd\u03b5\u03c2 \u03bd\u03af\u03ba\u03b7\u03c3\u03b1\u03bd \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf; \u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03c9\u03bd&nbsp;Yamanaka factors&nbsp;&#8211; \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd Oct4, Sox2, Klf4 \u03ba\u03b1\u03b9 c-Myc &#8211; \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03be\u03b5\u03c0\u03b5\u03c1\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd iPSC \u03ba\u03b1\u03b9 \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2. \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c3\u03c4\u03bf&nbsp;Babraham Institute&nbsp;\u03c4\u03bf\u03c5 Cambridge \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03bf \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae, \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c9\u03c2&nbsp;maturation-phase transient reprogramming (MPTR), \u03c0\u03bf\u03c5 \u00ab\u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9\u00bb \u03c4\u03bf\u03bd \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c7\u03c1\u03cc\u03bd\u03bf \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":9483,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35,863],"tags":[1609,1355,1610,791],"class_list":["post-9468","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-epistimh","category-ygeia","tag-babraham-institute","tag-cambridge","tag-antigiransi","tag-791"],"_links":{"self":[{"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=\/wp\/v2\/posts\/9468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9468"}],"version-history":[{"count":0,"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=\/wp\/v2\/posts\/9468\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=\/wp\/v2\/media\/9483"}],"wp:attachment":[{"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.upflow.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}